Blar i forfatter "Harder, Jennifer L."

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    • Correlation between baseline GFR and subsequent change in GFR in Norwegian adults without diabetes and in Pima Indians 

      Melsom, Toralf; Nair, Viji; Schei, Jørgen; Mariani, Laura; Stefansson, Vidar Tor Nyborg; Harder, Jennifer L.; Jenssen, Trond Geir; Solbu, Marit Dahl; Norvik, Jon Viljar; Looker, Helen; Knowler, William C.; Kretzler, Matthias; Nelson, Robert G.; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-28)
      <p><i>Rationale & Objective - </i>An elevated glomerular filtration rate (GFR), or renal hyperfiltration, may predispose individuals to subsequent rapid GFR decline in diabetes, obesity, and metabolic syndrome. Although this hypothesis is supported by results of experimental studies, the importance of hyperfiltration at the population level remains controversial. We investigated whether higher ...

    • Molecular programs associated with glomerular hyperfiltration in early diabetic kidney disease 

      Stefansson, Vidar Tor Nyborg; Nair, Viji; Melsom, Toralf; Looker, Helen C.; Mariani, Laura H.; Fermin, Damian; Eichinger, Felix; Menon, Rajasree; Subramanian, Lalita; Ladd, Patricia; Harned, Roger; Harder, Jennifer L.; Hodgin, Jeffrey B.; Bjornstad, Petter; Nelson, Peter J.; Eriksen, Bjørn Odvar; Nelson, Robert G.; Kretzler, Matthias (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-31)
      Hyperfiltration is a state of high glomerular filtration rate (GFR) observed in early diabetes that damages glomeruli, resulting in an iterative process of increasing filtration load on fewer and fewer remaining functional glomeruli. To delineate underlying cellular mechanisms of damage associated with hyperfiltration, transcriptional profiles of kidney biopsies from Pima Indians with type 2 ...